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The impairment of HMGB1 operate contributes to elevated mitochondrial DNA hurt. While in the SCA1 mouse design, around-expression from the HMGB1 protein via an released virus vector bearing the HMGB1 gene facilitates restore of your mitochondrial DNA harm, ameliorates the neuropathology along with the motor deficits, and extends the lifespan of tho… Read More

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